A grizzly bear named Boog (Martin Lawrence), domesticated by a park ranger, Beth (Debra Messing), helps deer friend Elliot (Ashton Kutcher) escape from the mullet-sporting hunter, Shaw.

When the animals escape to the forest the pair become lost just as hunting season begins, made worse by the fact Boog doesn't know how to survive outside of his beloved ranch.

Elliott and Boog develop a strong bond not only between themselves but also with the wild animals and attempt to drive the hunters out of the forest.